Dr. G. Venkat Sai, Dr. N. N. Anand


Introduction: Risk factor for stroke includes diabetes, hypertension, smoking and hyperlipidemia and these have been linked to abnormalities of haematology and coagulation such as increased fibrinogen. The present study is designed to investigate the association between plasma fibrinogen levels and acute stroke.

Methodology: The present study was a cross sectional study done in the Medicine ward/ICU of a tertiary care hospital. Plasma fibrinogen level was done of 50 patients presenting with acute stroke admitted in Medi- cine ward/I.C.U of sree balaji medical college& hospital. Detailed  history was taken to find out the risk factors such as hyper- tension, diabetes, Smoking and overweight. In addition to routine investigations as per standard protocol in the evaluation of stroke patient, fasting plasma fibrinogen level was estimated.

Results: The mean age in the present study was 58.52 years. The maximum numbers of patients were in the age group 60-69 years. In 86% of cases were having higher fibrinogen level. There were 23(46%) smokers among patients. Non smokers, Normotensives, Non obese and non diabetics had higher fibrinogen levels than smokers which were not statistically significant.

Conclusion: Mean fibrinogen level was lower in patients of acute stroke with any of risk factors like smoking, hypertension, diabetes and obese than in patients of acute stroke without any of these risk factors. This differ- ence was not statistically significant in this study but further large study can be planned to prove this


Acute Stroke, Fibrinogen, Hypertension, Diabetes

Full Text:



relation to personal history of prevalent hypertension, diabe- tes, stroke, intermittent claudication, coronary heart disease and family history. The Scottish Heart Health study. Br Heart J 1993; 69:338-342.

Fu A and Nair S K. Age effect on fibrinogen and albumin synthesis in humans. Am J PhysiolEndocrinolMetab 1998; 275: 1023-1030.

Ernst E. Regional variations in plasma fibrinogen levels. Ann of internal medicine 1991;115(4):329-330.

Meade TW, Chakrabarti R, Haines AP, North WR, Stirling

Y. Characteristics affecting fibrinolytic activity and plasma fibrinogen concentration. BMJ 1979; 1: 153-56.

Lip GYH. Fibrinogen and cardiovascular disorders. QJM 1995; 88: 153-6.

Anjula Jain, HL Gupta Shashi Narayan. Hyper fibrino- genemia in Patients of Diabetes Mellitus in Relation to Gly- cemic Control and Urinary Albumin Excretion Rate. JAPI 2001;49:227-230.

Sechi LA, Zingaro L, Catena C, Casaccio D, Marchi SE. Relationship of fibrinogen levels and hemostatic abnormali- ties with organ damage in hypertension. Hypertension 2000;36:978.

Meade TW, Chakrabarti R, Haines AP, North WR, Stirling

Y. Characteristics affecting fibrinolytic activity and plasma fibrinogen concentration. BMJ 1979; 1: 153-56.

Barazzoni R, Zanetti MG. Kiwanuka DE, Carraro P, Tiengo A, Tessari P. Increased fibrinogen production in type 2 dia- betic patients without detectable vascular complications: cor- relation with plasma glucagon concentrations. The Journal of Clinical Endocrinology and Meta bolism2000;85:3121-3125.

Mistry P, Chawla KP, Rai HP, Jaiswal P. Plasma fibrinogen levels in stroke. J Postgrad Med 1990;36:1-4

Smith WS, Johnston SC, Easton JD. Cerebrovascular diseas- es. In: Kasper DL, FauciAS, Longo DL, Braunwald E, Hauser SL, Jameson LJ, editors.

ternal Medicine. Vol2.16th Edn. New York: McGraw Hill;2005.p.2372-2393.

Rand ML, Murray RK. Hemostasis and thrombosis. In: Mur- ray K, Granner DK, Mayes PA, Rodwell VW, editors. Har-

ew Delhi:

McGraw Hill; 2003.p.598-608.

Diminno G, Mancini M. Measuring plasma fibrinogen to predict stroke and myocardial infarction. Arteriosclerosis 1990; 10:1-7.

Hazra B, Sengupta N, Saha SK, Guha S, Das B, Banerjee AR. A study of plasma fibrinogen level in acute stroke pa- tients in Calcutta. Indian journal of physiology and allied sci- ences 1997;51:76-80


  • There are currently no refbacks.