Dr Samarat, Dr Kiran L Hunashikatti


Hypertension is one of the leading causes of death and disability among adults all over the world and emerging health problem in India. Alterations in the intracellular free Calcium regulation as well as disturbances of extracellular calcium homeostasis have been observed in patients with essential hypertension. To study the levels of serum Calcium in patients with primary hypertension and correlate the serum Calcium levels with severity of disease. Information for the study was collected from patients admitted to S.NIJALINGAPPA MEDICAL COLLEGE AND HANGAL SHRI KUMARESHWAR Hospital and Research center, Bagalkot from April 2018
to August 2019. Patients met inclusion criteria were studied. A Comparative Study was done. Serum calcium was done in total 164 patient which were divided equally in 3 groups Stage I Hypertensives, Stage II Hypertensives, and Controls, 41 patients in each groups of Hypertension and 82 patients in control group, results were obtained compared. In patients of Essential hypertension mean serum Calcium levels were found to be low in comparison to Normotensives. Further, Stage II Hypertensive patient has more reduced levels of serum calcium than Stage I hence low Serum Calcium levels were associated as the severity of the disease increases.



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Anchala R, Kannuri NK, Pant H, Khan H, Franco OH, Di Angelantonio E, et

al. Hypertension in India. J Hypertens [Internet]. 2014;32(6):1170–7. Available



Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global

burden of hypertension: analysis of worldwide data. Lancet (London, England)

[Internet]. 2005 Jan 15 [cited 2016 Aug 30];365(9455):217–23. Available


Bell K, Twiggs J, Olin BR. Hypertension : The Silent Killer : Updated JNC-8

Guideline Recommendations. Alabama Pharm Assoc. 2015;1–8.

Carretero OA, Oparil S. Clinical Cardiology : New Frontiers. Am Hear Assoc.


Messerli FH, Williams B, Ritz E. Essential hypertension. 2007;370.

Staessen JA, Wang J, Bianchi G, Birkenhäger WH. Essential hypertension.


Hypertension E. Clinical Cardiology : New Frontiers. 2000;329–35.

Meneton P, Jeunemaitre X, Wardener HEDE, Macgregor GA. Links Between

Dietary Salt Intake , Renal Salt Handling , Blood Pressure , and Cardiovascular

Diseases. 2018;679–715. 9. Takahashi H, Yoshika M, Komiyama Y, Nishimura M. The central mechanism underlying hypertension : a review of the roles of sodium ions , epithelial sodium channels , the renin – angiotensin – aldosterone system , oxidative

stress and endogenous digitalis in the brain. 2011;34(11):1147–60. Available


Blood R, To F. Genetic and Non-Genetic Basis of Essential Hypertension :

Maladaptation of Human Civilization to High Salt Intake. 1998;

Jha K. Serum Calcium in Essential Hypertension and its Co-relation with

Severity of the Disease. Adv Stud Biol. 2011;3(7):319–25.

Peer Reviewed Title : Calcium and Hypertension Journal Issue : Author :

Martinez , Christina , University of California , Los Angeles Publication Date :

Permalink : Keywords : Calcium , Hypertension Abstract : Hypertension affects

millions of Americans . . 1998;4(2):2–6.

Karen L. Margolis, Roberta M. Ray, Linda Van Horn et al. Pressure : the

Women ‘ s Health Initiative randomized trial. NIH Public Access.


Ranjani G. Estimation of serum calcium and serum phosphorus levels in newly

detected essential hypertensive patients. 2017;4(9):47–53.

Article O, Pawade YR, Ghangale SS, Apte IC, Nagdeote AN, Warade JP.

Serum Calcium : Can It Be A Diagnostic And Prognostic Marker In Essential

Hypertension ? 2011;5(1):58–62.

Sharma B, Sarmah D. Serum calcium and magnesium in patients with Essential

hypertension and their first degree relatives. Int J Basic Med Sci Pharm[Internet]. 2012;2(2):66–9. Available from:

Lian IA, Åsberg A. Should total calcium be adjusted for albumin ? A

retrospective observational study of laboratory data from central Norway.


Jorde R, Sundsfjord J, Fitzgerald P, Bønaa KH, Jorde R, Sundsfjord J, et al.

Serum Calcium and Cardiovascular Risk. 1999;484–90.

Halhali A, Diaz L, Avila E, Ariza AC, Garabedian M, Larrea F. Decreased fractional urinary calcium excretion and serum 1,25-dihydroxyvitamin D and IGF-I levels in preeclampsia. J Steroid Biochem Mol Biol. 2007 Mar;103(3–5):803–6.

Ferrier KE, Muhlmann MH, Baguet JP, Cameron JD, Jennings GL, Dart AM,

et al. Intensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic hypertension. J Am Coll Cardiol. 2002 Mar;39(6):1020–5.

Stamler R, Stamler J, Riedlinger WF, Algera G, Roberts RH. Weight and blood

pressure. Findings in hypertension screening of 1 million Americans. JAMA.1978 Oct;240(15):1607–10.

Hill C, Carolina N, Hill C, Carolina N. NIH Public Access. 2010;124(5)


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