EVALUATION OF VASCULAR AGING AND ARTERIAL STIFFNESS IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND ASSOCIATED HYPERTENSION

Dr. Geeta Sheth, Dr. Shahid Ansari

Abstract


Background: Patients with chronic kidney disease (CKD) on dialysis have high risk of cardiac diseases. Vascular aging (VA) and arterial stiffness (AS) are the major determinants of cardiovascular events. The present study assessed the parameters of VA and AS by oscillometric device in patients with CKD and associated hypertension.

Materials and Methods: A prospective study was conducted in patients with CKD on dialysis with associated hypertension. Central blood pressure (BP) and AS were measured using the Mobil-O-Graph® PWA. It provides information about peripheral BP, vascular age, augmentation index and PWV. This validated device is a commercially available branchial oscillometric ambulatory BP monitor. Statistical analysis was performed using Chi-square, sample t and Mann Whitney U test.

Results: A total of 303 patients with a mean age of 50.70 years were included in this study. The mean age was significantly higher in patients with large arteries of abnormal AS (64.05 years) (p<0.001). The mean VA was significantly higher in patients with average large arteries than normal large arteries (p<0.001). A significant association was observed between large normal, average and abnormal AS in peripheral systolic BP, pulse pressure, mean arterial BP and pulse wave velocity (PWV, [p<0.001]). Significant increase in trend in VA and PWV were observed with increasing age (p<0.001). A significant association was observed between PWV and body mass index, VA, AS and peripheral and central BP (p<0.001).

Conclusion The overall observation suggests an increasing trend in oscillometric measurement of PWV, VA, AI with increase in the severity of AS. Theses parameters are indicative of cardiac events associated with CKD.


Keywords


Augmentation index, blood pressure, cardiovascular, oscillometric, pulse wave.

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References


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