Dr. Vikas Goyal, Dr. Abhijat Kulshreshtha


Neoplasms constitute the most important lesions of the breast. Commonest are the neoplasms arising
from the epithelial component, which constitute the glandular element of the breast. The most common
type of carcinoma is inltrative ductal carcinoma followed by lobular carcinoma and then other smaller groups. Many
prognostic factors have been identied in breast carcinoma. The grading of breast carcinomas is one of the most useful
prognostic indicators. When combined with histological tumour type and race of the patient, nuclear grade is a most powerful
predictor of tumour aggressiveness. Tumour angiogenesis as a prognostic marker is a latest issue. A number of studies have
found that highly vascular carcinomas have a poorer prognosis than those of low vascularity. In present study an attempt has
been made to correlate nuclear grading with microvessel density due to angiogenesis so as to develop a new criterion for
assessing the prognosis of different histomorphological types of carcinoma breast. Nuclear grading of the lesions was done
according to the Nottingham modication of Bloom Richardson system (1991). All sections were assessed for angiogenesis by
calculating MVD. The MVD increased from grade I to grade II to grade III lesions. On statistical analysis there was a positive
high correlation between nuclear grade and microvessel density. Present study reveals that microvessel density correlate
positively with nuclear grade.


breast carcinoma, nuclear grading, angiogenesis, microvessel density

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