Hematological Changes in Megaloblastic anemia: A study of 25 cases

Vijay Kumar Sinha, Subhash Chandra Jha, Parshuram Prasad, Dilip Kumar Pandey


Materials and Methods: A teaching hospital-based retrospective study was done for a period of 1 year.
25 cases of megaloblastic anemia were analyzed and we correlated signs, symptoms, and
hematological investigations.
Results: Totally, 25 patients with megaloblastic anemia in the above said period were studied. The patient's age group was
ranged from 12 years to 87 years .Male female ratio was 4:1. Megaloblastic anemia was observed in all the cases. Pancytopenia
was seen in all cases. 25 patients had isolated vitamin B12 deciency. 3 patients had both Folic acid and vitamin B12 deciency.
One had only isolated Folic acid deciency.
Conclusion: Megaloblastic anemia is one of the common causes of undiagnosed anemia, and the treatment is simple and
easily affordable. If left untreated, it can lead to morbidity both because of anemia and attendant neurological involvement.


Megaloblastic anemia, Vitamin B12, Folic Acid, Pancytopenia

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