HIV NEUROPATHY DRUG NAIVE PLHA PATIENTS AND IT'S CORRELATION WITH GLYCEMIC STATUS IN CENTRAL INDIA.

Somnath Singh Raghuvanshi, Tribhuvan Nath Dubey, Himanshu Sharma, Rita Saxena

Abstract


The sensory neuropathies are still prevalent as the most frequent neurological disorder associated with
HIV infection and its treatment with ART. There are two major types of HIV-associated distal sensory
peripheral neuropathies: primary HIV-associated distal sensory polyneuropathy (HIV-DSP) and ART toxic neuropathy (ATN),
together which affect approximately 30–67% of patients with advanced HIV disease.
AIM: association of HIV neuropathy & its correlation with glycemic status.
MATERIAL & METHODS: After obtaining prior ethical clearance, treatment naïve PLHA (person living with HIV/acquired
immunodeciency syndrome (AIDS)) patients were included in the study and we carried out a cross-sectional study of the HIV
seropositive patients in inpatient and outpatient clinic of the Gandhi Medical College, Bhopal, from December 2011 to
December 2012.
RESULTS: Impaired fasting glucose was signicantly higher in neuropathy group by NCS examination (61.9%) than nonneuropathy
group (31.2%), p=0.009 . Impaired glucose tolerance is signicantly higher in clinical neuropathy group (75.9%)
than non-neuropathy group (28.3%), p=0.009.
CONCLUSION : The dysglycemia is more common in the hiv patients and both dysglycemia and hiv associated with
neuropathy or hiv patients are more prone to dysglycemia.


Keywords


Human Immunodefeciency Virus , Plha , Nerve Conduction Study . Dysglycemia.

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References


Keswani SC, Pardo CA, Cherry CL, Hoke A, McArthur JC. HIV-associated sensory neuropathies. AIDS. 2002; 16:2105–2117. [PubMed: 12409731]

Bacellar H, Munoz A, Miller EN, Cohen BA, Besley D, Selnes OA, et al. Temporal trends in the incidence of HIV-1-related neurologic diseases: Multicenter AIDS Cohort Study, 1985–1992. Neurology. 1994; 44:1892–1900. [PubMed: 7936243]

McArthur JC, Brew BJ, Nath A. Neurological complications of HIV infection. Lancet Neurol. 2005; 4:543–555. [PubMed: 16109361]

Ellis, R.; Rosario, D.; Clifford, D.; McArthur, J.; Simpson, D.; Alexander, T., et al. CROI. Montreal, Canada: 2009. Persisting high prevalence of HIV distal sensory peripheral neuropathy in the era of cART: correlates in the CHARTER study. [Paper #461]

Wulff EA, Wang AK, Simpson DM. HIV-associated peripheral neuropathy: epidemiology, pathophysiology and treatment. Drugs. 2000; 59:1251–1260. [PubMed: 10882161]

Cornblath DR, McArthur JC. Predominantly sensory neuropathy in patients with AIDS and AIDSrelated complex. Neurology. 1988; 38:794–796. [PubMed: 2834669]

Barohn RJ, Gronseth GS, LeForce BR, McVey AL, McGuire SA, Butzin CA. Peripheral nervous system involvement in a large cohort of human immunodeficiency virus-infected individuals. Arch Neurol. 1993; 50:167–171. [PubMed: 8381649]

Griffin, JW.; Crawford, TO.; McArthur, JC. Peripheral neuropathies associated with HIV infection. In: Gendelman, HE.; Epstein, E.; Lipton, SA.; Swindells, S., editors. The neurology of AIDS. New York: Chapman & Hall; 1998. p. 275-291.

Brinkman K, Hofstede J, Burger D, Smeitink J, Koopmans P. Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway. AIDS. 1998; 12:1735–1744. [PubMed: 9792373]

Brew BJ, Tisch S, Law M. Lactate concentrations distinguish between nucleoside neuropathy and HIV neuropathy. AIDS. 2003; 17:1094–1096. [PubMed: 12700465]

Cherry CL, Gahan ME, McArthur J, Lwein SR, Hoy JF, Wesselingh SL. Exposure to dideoxynucleosides is reflected in lowered mitochondrial DNA in subcutaneous fat. J AcquirImmune Defic Syndr. 2002; 30:271–277. [PubMed: 12131563]

. Banerjee S, McCutchan JA, Ances BM, Deutsch R, Riggs PK, Way L, Ellis RJ. Hypertriglyceridemia in combination antiretroviral-treated HIV-positive individuals: potential impact on HIV sensory polyneuropathy. AIDS. 2011; 25:F1–F6. [PubMed: 21150557]

Guidelines for HIV Testing‑National AIDS Control Organisation.National HIV testing network operational guidelines NACO Document.Operational Characteristics of Commercially available Assays to Determine Antibodies to HIV‑1 and/or HIV‑2 in Human Sera.14.

. Cherry CL, Affandi JS, Imran D, Yunihastuti E, Smyth K, Vanar S,et al. Age and height predict neuropathy risk in patients with HIV prescribed stavudine. Neurology 2009;73:315‑20.


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