Abhishek Kumar Verma, Kamlesh Taori, Hetal Boricha


INTRODUCTION: There has been a constant association of adverse clinical outcome in myocardial
infarction (MI) patients with acute kidney injury (AKI). However, whether AKI contributes to an excess risk
of cardiovascular events is still controversial, as very few studies are conducted in this context and less amount of knowledge
regarding AKI's short-term effects after its occurrence as a complication of AMI, so this study was performed.
AIM: To nd the incidence of AKI in post MI patients, study their clinical prole and outcome of AKI in post MI patients.
MATERIAL AND METHOD: Prospective observational study was undertaken in Saraswathi Medical College and Hospital,
Bareilly including 100 patients admitted in the ICU, emergency and ward from 1stMay 2019 to 31stNov 2019. They were
subjected to careful history taking and detailed clinical examination; routine investigations were done. The data was
computed and was statistically analyzed.
RESULTS: Out of 100, 36 patients had AKI. Mean age of the patients with AKI was 50± 6.1years and those without AKI was
53±5.9 years. Out of 100, 44 had inferior wall MI, 36 had anterior wall MI and 20 had NSTEMI. Mean fasting blood glucose
(mg/dL) in patients without AKI was 94.7±32 and in those with AKI was 145±40. Mean troponin I(ng/ml) was 2.4±3.4 in
patients without AKI and 5.29±7.1in those with AKI which was found statistically signicant (p value=0.015). Mean urea
(mg/dL) and creatinine (mg/dL) was 33.9±11.9 and 0.74±0.11 respectively in patients without AKI and with AKI was 70±48.9
and 2±1.45 respectively. Patients with AKI after MI had a more number of complications like arrhythmia, heart failure,
hypotension, LVEF (<30%), rupture (free wall or septum or papillary muscle) as compared to patients without AKI. Mortality in
patients without AKI was 4 and in patients with AKI was 6 .
CONCLUSION: High troponin I and older age are the most important risk factors for AKI in patients with acute MI. Post-MI
complications and mortality in patients with AKI was more than that in patients without AKI. Careful monitoring of susceptible
patients in ICU is recommended for early detection and management of AKI in patients with MI.

Full Text:



Kasper DL, Fauci AS, Hauser SL, Longo DL, Jamesone JL,Loscalzo J. Harrison ‘s principles of internal medicine (20th edition ) New York : McGraw Hill Education 2018;2: 2099

Song D, de Zoysa JR, Ng A, Chiu W: Troponins in acute kidney injury. Ren Fail 34: 35–39, 2012

Hoke TS, Douglas IS, Klein CL,He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S: Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol 18: 155–164, 2007

Ko GJ, Grigoryev DN, Linfert D, Jang HR,Watkins T, Cheadle C,Racusen L, Rabb H: Transcriptional analysis of kidneys duringrepair from AKI reveals possible roles for NGAL and KIM-1 asbiomarkers of AKI-to-CKD transition. Am J Physiol Renal Physiol298: F1472–F1483, 2010

Christov M,Waikar SS, Pereira RC, Havasi A, Leaf DE, Goltzman D, Pajevic PD,Wolf M, Ju¨ppner H: Plasma FGF23 levels increaserapidly after acute kidney injury. Kidney Int 84: 776–785, 2013

Leaf DE, Waikar SS, Wolf M, Cremers S, Bhan I, Stern L:Dysregulated mineral metabolism in patients with acute kidneyinjury and risk of adverse outcomes. Clin Endocrinol (Oxf) 79:491–498, 2013

Kasper DL, Fauci AS, Hauser SL, Longo DL, Jamesone JL, Loscalzo J. Harrison ‘s principles of internal medicine (20th edition ) New York : McGraw Hill Education 2018;2: 2104

Kirsten E. Fleischmann, Fox CS et al. Acute Kidney Injury in Myocardial Infarction. Massachusetts. NEJM Journal Watch.2012

Chirag R. Parikh, Steven G, Coca DO; Yongfei MS,Long-term Prognosis of Acute Kidney Injury After Acute Myocardial Infarction. Arch Intern Med. 2008;168(9):987-995.

Meier P, Lansky AJ, Baumbach A. Almanac 2013: acute coronary syndromes. Heart. 2013; 99: 1488-1493.

Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC). Steg PG, James SK, Atar D, Badano LP, Blömstrom-Lundqvist C, Borger MA, et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2012;33:2569-619.


  • There are currently no refbacks.